Scleroderma

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Cause and Risk Factors

The cause of scleroderma is unknown. A combination of factors (e.g., genetic, environmental) may contribute to development of the disease. Certain inherited antigens (cell markers), called human leukocyte antigens (HLA) are associated with an increased risk for scleroderma.


Environmental risk factors include exposure to silica dust (e.g., in coal and gold miners), exposure to certain chemicals (e.g., vinyl chloride, epoxy resin, pesticides) and solvents (e.g....Read the full article