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Signs and SymptomsSigns and Symptoms Symptoms of ankylosing spondylitis usually develop gradually. Early signs include pain, tenderness, and stiffness in the lower back. Symptoms often are more severe upon waking in the morning and with rest, and often improve with activity as the day goes on. As the disease progresses, pain may become persistent and interfere with sleep. Pain and stiffness in the lower back (lumbar region) eventually ascends to the middle of the back (thoracic region) and then to the ...Read the full article
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