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Risk Factors and CausesRisk Factors and Causes The cause of ankylosing spondylitis is unknown, and the origin and development of the disease is not well understood. AS may result from a combination of genetic and environmental factors. Ankylosing spondylitis is associated with an inherited antigen (cell marker) called HLA-B27, and more than 90% of patients with the disease also have this antigen. AS also is associated with inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease. ...Read the full article
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